Clinical Trial Funding Opportunity Announcements—Webinars

The National Center for Complementary and Integrative Health (NCCIH) is pleased to host three webinars to announce its new clinical trial funding opportunity announcements (FOAs). NCCIH has developed a series of clinical trial FOAs for natural products studies and mind and body intervention studies. These webinars will convey important information to prospective grant applicants, including an overview of the research grant submission process and an in-depth discussion of the new FOAs and the peer-review process.

Technical Assistance Videocast for "HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)", RFA-AT-20-004

Date: March 02, 2020 Time: 2:30 p.m. ET

NCCIH will host a technical assistance videocast onRFA-AT-20-004: HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional). This Funding Opportunity Announcement (FOA) is a reissue of previous announcementRFA-AT-19-004. The purpose of this technical assistance videocast is to provide more detail about this funding opportunity and review specific criteria. All videocast registrants will have the opportunity to submit their questions to our webinar mailbox during the videocast at

Please register using this Eventbrite link.

This FOA encourages UG3/UH3 phased cooperative research applications to conduct efficient, large-scale pragmatic or implementation trials to improve pain management and reduce the unnecessary use of opioid medications. Please note:

  • Awards made under this FOA will initially support a 1-year, milestone-driven, planning phase (UG3), with possible transition to an implementation phase (UH3) of up to 4 years’ duration (5 years total for the two phases).
  • UG3 projects that have met the scientific milestone and feasibility requirements may transition to the UH3 phase.
  • The UG3/UH3 application must be submitted as a single application, following the instructions described in this FOA.
  • The overall goal of this initiative is to support the “real world” assessment of health care strategies and clinical practices, and procedures in health care systems that may lead to improved pain management along with a reduction in unnecessary opioid prescribing.
  • Results from the pragmatic trials supported by this reissue should inform policy makers, payers, doctors, and patients in the primary care, emergency department, hospital, or dental setting. This FOA requires that the intervention under study be embedded into health care delivery system, “real world” settings.
  • Studies can propose to integrate multi-modal or multiple interventions that have demonstrated efficacy into health care systems, or implement health care system changes to improve adherence to evidence-based guidelines.
  • Trials should be conducted across three or more health care systems (HCS) and will become part of and work with the NIH HCS Research Collaboratory supported through the NIH Common Fund. (See The NIH HCS Research Collaboratory Program has established a Collaboratory Coordinating Center (CCC) that is providing national leadership and technical expertise in all aspects of research with HCS. Awarded applicants will work with the HCS CCC ( to facilitate further planning and refinement of the proposed study in partnerships with health care delivery systems.

Webinar for "Emotional Well-Being: High-Priority Research Networks (U24, Clinical Trial Optional)", RFA-AT-20-003

Date: March 17, 2020 Time: 2:00 p.m. ET

This Notice is to inform potential applicants that the National Center for Complementary and Integrative Health (NCCIH), the National Institute on Aging (NIA), and the National Institute of Child Health and Human Development (NICHD) will hold a pre-application technical assistance webinar on RFA-AT-20-003, “Emotional Well-Being: High-Priority Research Networks (U24, Clinical Trial Optional)”. The intent of this webinar is to provide an overview of the initiative and to address applicant questions prior to preparing applications. The webinar is optional and not required for application submission.

How to participate in the pre-application webinars: the Q & A portion of the webinar will address prospective applicants’ questions; however, applicants are encouraged to submit their questions in advance of the webinar indicate “Emotional Well-Being” in the subject line of your email). Prospective applicants with inquiries concerning the FOA who are unable to participate in the Webinar are encouraged to contact the Scientific/Research contact listed in the Funding Opportunity Announcement (FOA).

NOTE: You must register for the webinar to attend.

Register now.


NCCIH’s New Approach to Funding Clinical Trials
Date: — April 18, 2017
A recent NCCIH Webinar addressed changes involving applications for investigator-initiated clinical trials.

New NCCIH Funding Opportunities for Mind and Body Clinical Trials
Date: — April 24, 2017
Learn about information presented during an April 24, 2017 webinar that addressed changes in the rules governing applications for clinical trials of mind and body interventions.

New NCCIH Funding Opportunities for Natural Products Clinical Trials
Date: — May 09, 2017
NCCIH hosted a webinar to address new data on funding clinical trials of natural products.