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Know the Science: How Medications and Supplements Can Interact

Interactions With Over-the-Counter Drugs

When people think about drug interactions, they often think about prescription drugs.

But some drugs that are available over the counter without a prescription can interact with supplements, too.

If you’re considering taking both an over-the-counter drug and a dietary supplement, it’s a good idea to talk with your health care provider or a pharmacist about possible interactions.

Which of these over-the-counter drugs may interact with herbal supplements?

 Aspirin

 Pseudoephedrine (a decongestant)

 Fexofenadine (Allegra)

 All of them

Yes, but this isn’t the only one. Try again.

You’re right. A variety of herbs may interact with aspirin to increase the risk of bleeding. Concentrated green tea supplements interact with pseudoephedrine. St. John’s wort interacts with fexofenadine (Allegra).