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Know the Science: 9 Questions To Help You Make Sense of Health Research

8. What does it mean when the results of a study are described as statistically significant but not clinically significant?

"Statistically significant" means the finding in the difference between the study groups is not likely to be due to chance. “Clinically significant” is a measure of the size of the effects observed in the study. For example, a study can find statistically significant differences between two treatment groups, but the differences are so small that they do not have clinical significance in terms of usefulness for patients or safety.