Skip to main content

Natural Products Clinical Trials Funding Opportunities

The following notices of funding opportunities (NOFOs) focus on natural products and target support of all phases of clinical intervention development. Natural products, also called nutritional approaches, include a variety of products, such as herbs (also known as botanicals), vitamins and minerals, and probiotics. 

The following categories are tied to the conceptual framework delineating the purpose of each stage of research. Investigation can be proposed at any stage along this continuum.

Basic

NIH Guide #: NOT-AT-21-006
Related Notice(s) or Announcement(s):
  • PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  • PA-20-184 - Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
  • PA-20-183 - Research Project Grant (Parent R01 Clinical Trial Required)
  • PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  • PA-20-196 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)
  • PA-20-194 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
Activity Code:

R01 Research Project Grant

R21 Exploratory/Developmental Research Grant

First Receipt Date:June 5, 2021
Expiration Date: September 8, 2024
Scientific/Research Contact(s):

Mechanistic and Translational

NIH Guide #: NOT-AT-21-006
Related Notice(s) or Announcement(s):
  • PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  • PA-20-184 - Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
  • PA-20-183 - Research Project Grant (Parent R01 Clinical Trial Required)
  • PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  • PA-20-196 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required)
  • PA-20-194 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
Activity Code:

R01 Research Project Grant

R21 Exploratory/Developmental Research Grant

First Receipt Date:June 5, 2021
Expiration Date: September 8, 2024
Scientific/Research Contact(s):
NIH Guide #: 

PAR-24-124

Activity Code:R61/R33 Exploratory/Developmental  Phased Award
First Receipt Date:February 4, 2024
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov
NIH Guide #: PAR-24-116
Activity Code:R33 Exploratory/Developmental Grants Phase II.
First Receipt Date:January 20, 2024
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

Intervention Refinement and Optimization

NIH Guide #: PAR-24-115
Activity Code:R01 Research Project Grant
First Receipt Date:January 21, 2024
Expiration Date: November 14, 2026
Scientific/Research Contact(s):

Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

NIH Guide #: 

PAR-24-124

Activity Code:R61/R33 Exploratory/Developmental Phased Award
First Receipt Date:February 4, 2024
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov
NIH Guide #: PAR-24-116
Activity Code:R33 Exploratory/Developmental Grants Phase II.
First Receipt Date:January 20, 2024
Expiration Date: November 14, 2026
Scientific/Research Contact(s):Sekai Chideya, M.D., MPH
Email: sekai.chideya@nih.gov

Efficacy

NIH Guide #: PAR-24-086
Activity Code:R01 Research Project Grant
First Receipt Date:January 20, 2024
Expiration Date: November 18, 2026
Scientific/Research Contact(s):

Beda Jean-Francois, Ph.D.  
Email: beda.jean-francois@nih.gov 

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required)

NIH Guide #: PAR-24-123
Activity Code:UG3/UH3 Exploratory/Developmental Phased Award Cooperative Agreement
First Receipt Date:February 4, 2024
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D. M.P.H 
Email: weberwj@mail.nih.gov 

NIH Guide #: PAR-24-125
Activity Code:U24 Resource-Related Research Projects – Cooperative Agreements
First Receipt Date:February 6, 2024
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D. M.P.H 
Email: weberwj@mail.nih.gov 

Effectiveness and Pragmatic Studies

NIH Guide #: PAR-24-086
Activity Code:R01 Research Project Grant
First Receipt Date:January 20, 2024
Expiration Date: November 18, 2026
Scientific/Research Contact(s):

Beda Jean-Francois, Ph.D.  
Email: beda.jean-francois@nih.gov 

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required)

NIH Guide #: PAR-24-123
Activity Code:UG3/UH3 Exploratory/Developmental Phased Award Cooperative Agreement
First Receipt Date:February 4, 2024
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D. M.P.H 
Email: weberwj@mail.nih.gov 

NIH Guide #: PAR-24-125
Activity Code:U24 Resource-Related Research Projects – Cooperative Agreements
First Receipt Date:February 6, 2024
Expiration Date: July 15, 2026
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D. M.P.H 
Email: weberwj@mail.nih.gov 

Dissemination and Implementation Research

NIH Guide #: PAR-22-109
Activity Code:R21 Exploratory/Developmental Research Grant
First Receipt Date:May 16, 2022
Expiration Date: May 8, 2025
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D., M.P.H.
Email: weberwj@mail.nih.gov

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

NIH Guide #: PAR-22-105
Activity Code:R01 Research Project Grant
First Receipt Date:May 15, 2022
Expiration Date: May 8, 2025
Scientific/Research Contact(s):

Wendy Weber, N.D., Ph.D., M.P.H.
Email: weberwj@mail.nih.gov

Public reporting burden for this collection of information is estimated to average 1 minute per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a currently valid OMB control number. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to: NIH, Project Clearance Branch, 6705 Rockledge Drive, MSC 7974, Bethesda, MD 20892-7974, ATTN: PRA (0925-0648). Do not return the completed form to this address.