Selected Research Results
NCCIH funds a wide variety of research studies, primarily focusing on three areas: mind and body practices, natural products, and pain. We also conduct research at the National Institutes of Health laboratories in Bethesda, Maryland.
This page provides plain language summaries of a few of the studies that NCCIH has supported or conducted. The summaries are ordered by date, with the most recent studies first. For more information, see this full list of published NCCIH-funded research studies in PubMed.
When Taken Orally, Δ9-Tetrahydrocannabinol With Cannabidiol Can Result in Stronger Drug Effects Than Δ9-Tetrahydrocannabinol Alone
New research contradicts prior claims and clarifies the interactions between the two main cannabinoids—Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD)—when they are ingested orally as part of an edible cannabis product. The study’s findings suggest that CBD can inhibit the metabolism of Δ9-THC when the two are consumed together, leading to increased effects than when the same dose of Δ9-THC is consumed without CBD. The study, recently published in the journal JAMA Network Open, was led by researchers at Johns Hopkins University School of Medicine and partially funded by the National Center for Complementary and Integrative Health.
New Study Fails To Replicate Research That Suggested a Novel Activity of Piezo1
Contrary to the findings of a study published 2 years ago, the ion channel Piezo1 does not react to microbial single-stranded RNA (ssRNA) in the gut, according to a new study by investigators from the National Center for Complementary and Integrative Health (NCCIH) and The Scripps Research Institute. The new study, which was funded by the Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®, was published in the journal eLife.
New Study Explores How Instructions and Learning Affect Pain Perception and the Brain
Both learning and verbal instructions influence expectations and people’s perception of pain, but responses differ in different regions of the brain, according to a new study by researchers from the National Institutes of Health, published in eLife. The findings of this study, which was conducted by the intramural research programs of the National Center for Complementary and Integrative Health and the National Institute of Mental Health, may help researchers develop better treatments for pain.
U.S. National Survey Identifies Associations Between Chronic Severe Back Pain and Disability
According to a new analysis of national survey data, 8.2 percent of American adults have chronic severe back pain, and about three-quarters (74.8 percent) of those with chronic severe back pain have difficulties with mobility, social participation, self-care, or work participation. The analysis, conducted by researchers at the Université de Montréal and the National Center for Complementary and Integrative Health, was published in The Journal of Pain.
Researchers Identify a Phospholipid Responsible for the Immunomodulatory Activity of an Important Gut Bacterium
In a recent study published in Nature and partly funded by the National Center for Complementary and Integrative Health, researchers at Harvard Medical School and the Broad Institute of MIT and Harvard identified a specific lipid responsible for the immunomodulatory properties of the gut bacterium Akkermansia muciniphila and explored the mechanisms by which it exerts its effects.
Yogic Breathing Affects Cerebrospinal Fluid Dynamics During Breathing Practice
Practicing yogic breathing may have an effect on an individual’s cerebrospinal fluid (CSF) dynamics—the movement, flow, and circulation of the CSF—and on the health of the central nervous system, according to a new study published in the journal Scientific Reports. This study, conducted by researchers at Oregon Health & Science University and funded by the National Center for Complementary and Integrative Health, the National Institute on Aging, and the National Center for Advancing Translational Sciences, was the first to analyze the impact of deep breathing on CSF dynamics.
New Analysis Confirms Benefit of Supplements for Slowing Age-Related Macular Degeneration
Substituting lutein and zeaxanthin for beta-carotene in a dietary supplement that slows the progression of age-related macular degeneration (AMD) increased the supplement’s effectiveness and reduced the risk of lung cancer due to beta-carotene, according to a follow-up analysis of a large clinical trial. This new report, which analyzed 10 years of data from Age-Related Eye Disease Study 2 (AREDS2), was funded by the National Institutes of Health and published in JAMA Ophthalmology.
New Research Shows Variation Among Individuals in Brain Representations of Pain
The brain’s processing of pain differs among people, with more individual variation in some brain regions than others, according to a new study from an international group of institutions in South Korea, Germany, the Netherlands, France, Canada, and the United States, including the National Center for Complementary and Integrative Health. The findings of this study, published in the journal Nature Neuroscience, may help researchers identify potential targets for personalized assessment and treatment of pain.
Psychological Effects of Yoga and Physical Therapy on Low-Back Pain and Disability
Improvements in perceived stress may contribute to a reduction in low-back pain (LBP) and related disability in people with chronic LBP who receive physical therapy (PT), according to a recent analysis of data. However, the effects of yoga and PT on other psychological factors, compared to an education control group, were small and did not significantly contribute to improvements in LBP or disability. The analysis was funded in part by the National Center for Complementary and Integrative Health (NCCIH) and published in the Journal of Orthopaedic & Sports Physical Therapy.
National Survey Data Show an Increase in the Percentage of Physician Office Visits That Include Complementary Health Approaches Between 2005 and 2015
The percentage of office visits at which physicians provided or recommended complementary health approaches more than tripled between 2005 and 2015, according to a new analysis of data from the National Ambulatory Medical Care Survey (NAMCS). The analysis, which was performed by investigators from the National Center for Complementary and Integrative Health and published in a recent issue of the Journal of Integrative and Complementary Medicine, also showed that visits that included complementary health primarily involved patients who were age 45 or older, female, non-Hispanic white, and covered by public or private health insurance.