Omega-3 Supplements: In Depth
What Are Omega-3s?
Omega-3s (short for omega-3 fatty acids) are a kind of fat found in foods and in the human body. They are also sold as dietary supplements.
- The omega-3s EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are found in seafood (fish and shellfish).
- Because of their chemical structure, EPA and DHA are sometimes referred to as long-chain omega-3s.
- A different type of omega-3, ALA (alpha-linolenic acid), is found in certain plant oils such as flaxseed, soybean, and canola oils and also in some other foods of plant origin, such as chia seeds and black walnuts.
- Most of the research discussed in this fact sheet focuses on EPA and DHA.
Several types of dietary supplements contain omega-3s.
- Fish oil supplements contain EPA and DHA.
- Fish liver oil supplements, such as cod liver oil, contain EPA and DHA, and they also contain vitamins A and D, in amounts that vary from product to product. Vitamins A and D can be harmful in excessive amounts.
- Krill oil contains EPA and DHA.
- Algal oils are a vegetarian source of DHA; some also contain EPA.
- Flaxseed oil contains ALA.
- For some health conditions, the evidence for benefits from seafood (fish and shellfish) is stronger than the evidence for omega-3 supplements.
- How could this happen? Here are some possibilities:
- Seafood may provide enough omega-3s; more may not be better.
- Other nutrients in seafood besides omega-3s may play a role in its benefits.
- Some of the benefits of seafood may result from people eating it in place of less healthful foods.
- There’s evidence that people who eat seafood have generally healthier lifestyles.
The Federal Government’s Dietary Guidelines for Americans 2015–2020 recommends that adults eat 8 or more ounces of a variety of seafood (fish or shellfish) per week for the total package of nutrients seafood provides, and that some seafood choices with higher amounts of EPA and DHA be included. Smaller amounts of seafood are recommended for young children.
Use of Omega-3 Supplements in the United States
According to the 2012 National Health Interview Survey, which included a comprehensive survey on the use of complementary health approaches in the United States, fish oil supplements are the nonvitamin/nonmineral natural product most commonly taken by both adults and children. The survey findings indicated that about 7.8 percent of adults (18.8 million) and 1.1 percent of children age 4 to 17 (664,000) had taken a fish oil supplement in the previous 30 days.
What Do We Know About the Effectiveness of Omega-3s?
Conditions Affecting the Circulatory System
- A 2011 evaluation of 17 studies indicated that people who eat seafood (fish and shellfish) one to four times a week are less likely to die of heart disease than those who rarely or never eat seafood.
- A 2018 analysis of 10 major omega-3 supplementation studies (77,917 total participants, all at high risk of heart disease), each of which involved at least 500 participants and a treatment duration of at least a year, found no evidence that omega-3s could reduce the risk of fatal or nonfatal coronary heart disease.
- In 2016, the U.S. Government’s Agency for Healthcare Research and Quality (AHRQ) did a comprehensive evaluation of 98 studies of omega-3s and heart disease, including both diet and supplementation studies. They did not find evidence that omega-3s can reduce the risk of heart attacks or death from heart disease.
- Several other analyses of the evidence have been done in the last few years (2012 or later), and like the 2018 analysis and the AHRQ report, most found little or no evidence for a protective effect of omega-3 supplements against heart disease. However, some earlier analyses suggested that omega-3s could be helpful. The difference between the newer conclusions and the older ones may reflect two changes over time:
- Public health messages that urge people to eat more seafood may have led to greater consumption of omega-3s from food. Additional omega-3s, beyond the amounts consumed by people who eat seafood, may not have extra benefits.
- More people are taking medicines that reduce the risk of heart attacks, such as statin drugs to treat high cholesterol. Omega-3s may not offer extra benefits beyond those of modern drug treatment.
- For more information on heart disease, see NCCIH’s Cardiovascular Disease Web page.
- Eating seafood (fish and shellfish) has been linked to a moderate reduction in the risk of stroke.
- According to the AHRQ report, there is some evidence that omega-3s from marine sources (such as fish oil) may reduce the risk of one type of stroke (ischemic stroke—the type caused by narrowing or blockage of a blood vessel in the brain), but omega-3s have not been shown to reduce total strokes or death from stroke.
- Triglycerides are a type of fat found in people’s blood. Excessive levels of triglycerides may raise the risk of heart disease. Dietary changes, weight control, and exercise are used to lower triglyceride levels. Some people also need to take medicine to lower their triglyceride levels.
- High doses of omega-3 fatty acids can reduce triglyceride levels.
- Several products containing omega-3s have been approved as prescription drugs to be used in combination with diet to reduce triglyceride levels in patients whose triglyceride levels are very high.
- The composition of these products is not the same as that of typical omega-3 supplements, and the testing and regulation of prescription drugs differ from those for dietary supplements. Therefore, the effects of these prescription products may not be the same as those of omega-3 dietary supplements.
Conditions Affecting the Brain, Nervous System, or Mental Health
- It’s uncertain whether omega-3 fatty acid supplements are helpful for depression. Although some studies have had promising results, a 2015 evaluation of 26 studies that included more than 1,400 people concluded that if there is an effect, it may be too small to be meaningful. Other analyses have suggested that if omega-3s do have an effect, EPA may be more beneficial than DHA and that omega-3s may best be used in addition to antidepressant medication rather than in place of it.
- Omega-3s have not been shown to relieve symptoms of depression that occur during pregnancy or after childbirth.
- Depression can be a serious illness. If you or someone in your family may have depression, consult a health care provider.
- For more information, see NCCIH’s Web page on depression.
- Some research indicates that people who eat more seafood may have a reduced risk of cognitive decline. However, omega-3 supplements haven’t been shown to help prevent cognitive impairment or Alzheimer’s disease or to improve symptoms of these conditions. For example, a large NIH-sponsored study completed in 2015 indicated that taking EPA and DHA supplements did not slow cognitive decline in older adults. The people studied were participants in a larger eye disease study, and all of them had age-related macular degeneration (AMD).
- It’s possible that omega-3s might have different effects in people with different genetic backgrounds. A 2017 research review suggested that people who carry a gene called APOE4, which is associated with an increased risk of Alzheimer’s disease, might benefit from taking DHA before developing signs of Alzheimer’s.
- For more information, see NCCIH’s Web page on cognitive function, dementia, and Alzheimer’s disease.
Omega-3s have also been studied for autism spectrum disorders, borderline personality disorder, multiple sclerosis, and schizophrenia, but the evidence regarding their effects on these conditions is inconclusive.
- The results of several small studies had suggested that taking omega-3 supplements might help relieve symptoms of dry eye disease. However, a 2018 NIH-sponsored study that tested omega-3 supplements for a full year in a larger group (535 study participants) with moderate-to-severe dry eye disease found that the supplements were no more helpful than a placebo (an inactive substance).
- Only a few studies have been conducted on omega-3s for retinitis pigmentosa, and these studies have not shown any clear evidence of beneficial effects.
- The types of omega-3s found in seafood and fish oil may be modestly helpful in relieving symptoms of rheumatoid arthritis and decreasing patients’ need for nonsteroidal anti-inflammatory drugs.
- Conventional medical treatment for rheumatoid arthritis can slow joint damage. If you have rheumatoid arthritis, don’t change your use of prescribed medications without consulting your health care provider.
- For more information, see NCCIH’s fact sheet on rheumatoid arthritis.
- The nutritional value of seafood is important during early development. The Dietary Guidelines for Americans 2015–2020 and guidance from the U.S. Food and Drug Administration and Environmental Protection Agency recommend that women who are pregnant or breastfeeding eat at least 8 ounces but no more than 12 ounces of a variety of seafood each week, from choices that are lower in methyl mercury. Methyl mercury can be harmful to the brain and nervous system if a person is exposed to too much of it.
- In 2016, AHRQ reviewed 143 studies that evaluated the effects of giving omega-3 supplements to pregnant or breastfeeding women or giving formulas with added DHA to infants. They found that when women took omega-3 supplements during pregnancy, their babies’ birth weight was slightly higher, but the risk of an undesirably low birth weight did not change. Also, when women took omega-3 supplements during pregnancy, their pregnancies lasted a little longer, but there was no effect on the risk of premature birth. Omega-3s were not found to have effects on any other aspects of the mothers’ or infants’ health or the infants’ long-term development. Aspects of the infants’ health that were not shown to be affected by omega-3s include growth after birth, visual acuity, long-term neurological and cognitive development, and the risks of autism, ADHD, learning disorders, and allergies.
- In a study published after the AHRQ report, scientists in Denmark gave high-dose fish oil supplements or placebos to 736 pregnant women during the third trimester of pregnancy. Children born to mothers who had taken fish oil were less likely to develop asthma or persistent wheezing in early childhood, and this was most noticeable in children whose mothers had low blood levels of EPA and DHA before they started to take the supplements. However, other studies that evaluated the effects of omega-3 supplementation during pregnancy on childhood asthma risk have had inconsistent results.
- Omega-3s have been studied for other conditions, with either inconclusive or negative results. These conditions include allergies, atopic eczema (an allergic skin condition), cystic fibrosis, diabetes, inflammatory bowel diseases (Crohn’s disease or ulcerative colitis), intermittent claudication (a circulatory problem), nonalcoholic fatty liver disease, and osteoporosis.
What Do We Know About the Safety of Omega-3s?
- Side effects of omega-3 supplements are usually mild. They include unpleasant taste, bad breath, bad-smelling sweat, headache, and gastrointestinal symptoms such as heartburn, nausea, and diarrhea.
- Several large studies have linked higher blood levels of long-chain omega-3s with higher risks of prostate cancer. However, other research has shown that men who frequently eat seafood have lower prostate cancer death rates and that dietary intakes of long-chain omega-3s aren’t associated with prostate cancer risk. The reason for these apparently conflicting findings is unclear.
- Omega-3 supplements may interact with drugs that affect blood clotting.
- It’s uncertain whether people with seafood allergies can safely take fish oil supplements.
NCCIH is supporting research on omega-3s.
- Currently, topics that NCCIH-funded researchers are investigating include:
- How changes in the intake of omega-3s and other fatty acids affect patients with migraine
- Which patients with depression might respond to EPA
- How genetic differences affect the fate of omega-3s in the body
- The effects of flaxseed, which is rich in ALA, in an animal model of ovarian cancer.
More To Consider
Take charge of your health—talk with your health care providers about any complementary health approaches you use. Together, you can make shared, well-informed decisions.
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- Age-Related Eye Disease Study 2 research group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013;309(19):2005-2015.
- Appleton KM, Sallis HM, Perry R, et al. Omega-3 fatty acids for depression in adults. Cochrane Database of Systematic Reviews. 2015;(11):CD004692. Accessed at https://www.cochranelibrary.com on November 28, 2016.
- Aung T, Halsey J, Kromhout D, et al. Associations of omega-3 fatty acid supplement use with cardiovascular disease risks. Meta-analysis of 10 trials involving 77,917 individuals. JAMA Cardiology. 2018;3(3):225-234.
- Balk EM, Adam GP, Langberg V, et al. Omega-3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review. Evidence Report/Technology Assessment no. 223. Rockville, MD: Agency for Healthcare Research and Quality; 2016. AHRQ publication no. 16-E002-EF.
- Bisgaard H, Stokholm J, Chawes BL, et al. Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring. New England Journal of Medicine. 2016;375(26):2530-2539.
- Brasky TM, Darke AK, Song X, et al. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. Journal of the National Cancer Institute. 2013;105(15):1132-1141.
- Chew EY, Clemons TE, Agrón E, et al. Effect of omega-3 fatty acids, lutein/zeaxanthin, or other nutrient supplementation on cognitive function. The AREDS2 randomized clinical trial. JAMA. 2015;314(8):791-801.
- Dry Eye Assessment and Management Study Research Group. N-3 fatty acid supplementation for the treatment of dry eye disease. New England Journal of Medicine. 2018;378(18):1681-1690.
- Grey A, Bolland M. Clinical trial evidence and use of fish oil supplements. JAMA Internal Medicine. 2014;174(3):460-462.
- Grosso G, Pajak A, Marventano S, et al. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014;9(5):e96905.
- He K, Song Y, Daviglus ML, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation. 2004;109(22):2705-2711.
- Kwak SM, Myung S-K, Lee YJ, et al. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Archives of Internal Medicine. 2012;172(9):686-694.
- Lee Y-H, Bae S-C, Song G-G. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Archives of Medical Research. 2012;43(5):356-362.
- Miles EA, Calder PC. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. British Journal of Nutrition. 2012;107(Suppl 2):S171-S184.
- Newberry SJ, Chung M, Booth M, et al. Omega-3 Fatty Acids and Maternal and Child Health: An Updated Systematic Review. Evidence Report/Technology Assessment No. 224. Rockville, MD: Agency for Healthcare Research and Quality; 2016. AHRQ publication no. 16(17)-E003-EF.
- Office of Dietary Supplements. Omega-3 Fatty Acids: Fact Sheet for Health Professionals. Office of Dietary Supplements Web site. Accessed at https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/ on November 23, 2016.
- Orchard TS, Pan X, Cheek F, et al. A systematic review of omega-3 fatty acids and osteoporosis. British Journal of Nutrition. 2012;107(Suppl 2):S253-S260.
- Querques G, Souied EH. The role of omega-3 and micronutrients in age-related macular degeneration. Survey of Ophthalmology. 2014;59(5):532-539.
- Rizos EC, Ntzani EE, Bika E, et al. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308(10):1024-1033.
- Sublette ME, Ellis SP, Geant AL, et al. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. Journal of Clinical Psychiatry. 2011;72(12):1577-1584.
- Sydenham E, Dangour AD, Lim WS. Omega 3 fatty acid for the prevention of cognitive decline and dementia. Cochrane Database of Systematic Reviews. 2012;(6):CD005379. Accessed at https://www.cochranelibrary.com on December 5, 2016.
- Szymanski KM, Wheeler DC, Mucci LA. Fish consumption and prostate cancer risk: a review and meta-analysis. American Journal of Clinical Nutrition. 2010;92(5):1223-1233.
- Anandan C, Nurmatov U, Sheikh A. Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis. Allergy. 2009;64(6):840-848.
- Bath-Hextall FJ, Jenkinson C, Humphreys R, et al. Dietary supplements for established atopic eczema. Cochrane Database of Systematic Reviews. 2012;(2):CD005205. Accessed at http://www.cochranelibrary.com on November 29, 2016.
- Bhargava R, Kumar P, Kumar M, et al. A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. International Journal of Ophthalmology. 2013;6(6):811-816.
- Black LI, Clarke TC, Barnes PM, Stussman BJ, Nahin RL. Use of complementary health approaches among children aged 4?17 years in the United States: National Health Interview Survey, 2007?2012. National health statistics reports; no 78. Hyattsville, MD: National Center for Health Statistics. 2015.
- Bloch MH, Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry. 2011;50(10):991-1000.
- Burckhardt M, Herke M, Wustmann T, et al. Omega-3 fatty acids for the treatment of dementia. Cochrane Database of Systematic Reviews. 2016;(4):CD009002. Accessed at http://www.cochranelibrary.com on November 25, 2016.
- Cabré E, Mañosa M, Gassull MA. Omega-3 fatty acids and inflammatory bowel diseases – a systematic review. British Journal of Nutrition. 2012;107(Suppl 2):S240-S252.
- Campbell A, Price J, Hiatt WR. Omega-3 fatty acids for intermittent claudication. Cochrane Database of Systematic Reviews. 2013;(7):CD003833. Accessed at http://www.cochranelibrary.com on November 29, 2016.
- Casula M, Soranna D, Catapano AL, et al. Long-term effect of high dose omega-3 fatty acid supplementation for secondary prevention of cardiovascular outcomes: a meta-analysis of randomized placebo controlled trials. Atherosclerosis. Supplements. 2013;14(2):243-251.
- Chowdhury R, Stevens S, Gorman D, et al. Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis. BMJ. 2012;345:e6698.
- Chua ME, Sio MC, Sorongon MC, et al. Relationship of dietary intake of omega-3 and omega-6 fatty acids with risk of prostate cancer development: a meta-analysis of prospective studies and review of literature. Prostate Cancer. 2012;2012:826254.
- Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002–2012. National health statistics reports; no 79. Hyattsville, MD: National Center for Health Statistics. 2015.
- Cooper RE, Tye C, Kuntsi J, et al. The effect of omega-3 polyunsaturated fatty acid supplementation on emotional dysregulation, oppositional behaviour and conduct problems in ADHD: a systematic review and meta-analysis. Journal of Affective Disorders. 2016;190:474-482.
- Covington MB. Omega-3 fatty acids. American Family Physician. 2004;70(1):133-140.
- Daviglus ML, Bell CC, Berrettini W, et al. National Institutes of Health State-of-the-Science Conference statement: preventing Alzheimer disease and cognitive decline. Annals of Internal Medicine. 2010;153(3):176-181.
- De Ley M, de Vos R, Hommes DW, et al. Fish oil for induction of remission in ulcerative colitis. Cochrane Database of Systematic Reviews. 2007;(4):CD005986 [edited 2008]. Accessed at http://www.cochranelibrary.com on December 5, 2016.
- Dennis CL, Dowswell T. Interventions (other than pharmacological, psychosocial or psychological) for treating antenatal depression. Cochrane Database of Systematic Reviews. 2013;(7):CD006795. Accessed at http://www.cochranelibrary.com on November 28, 2016.
- Farinotti M, Vacchi L, Simi S, et al. Dietary interventions for multiple sclerosis. Cochrane Database of Systematic Reviews. 2012;(12):CD004192. Accessed at http://www.cochranelibrary.com on November 29, 2016.
- Fusar-Poli P, Berger G. Eicosapentaenoic acid interventions in schizophrenia: meta-analysis of randomized, placebo-controlled studies. Journal of Clinical Psychopharmacology. 2012;32(2):179-185.
- Gillies D, Sinn JK, Lad SS, et al. Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database of Systematic Reviews. 2012;(7):CD007986. Accessed at http://www.cochranelibrary.com on December 5, 2016.
- Gunaratne AW, Makrides M, Collins CT. Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. Cochrane Database of Systematic Reviews. 2015;(7):CD010085. Accessed at http://www.cochranelibrary.com on November 28, 2016.
- Harris WS. Omega-3 fatty acids. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:577-586.
- Hartweg J, Perera R, Montori V, et al. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews. 2008;(1):CD003205 [edited 2009]. Accessed at http://www.cochranelibrary.com on November 29, 2016.
- He XX, Wu XL, Chen RP, et al. Effectiveness of omega-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. PLoS One. 2016;11(10):E0162368.
- Hu FB, Manson JE. Omega-3 fatty acids and secondary prevention of cardiovascular disease—is it just a fish tale? Archives of Internal Medicine. 2012;172(9):694-696.
- James S, Montgomery P, Williams K. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD). Cochrane Database of Systematic Reviews. 2011;(11):CD007992. Accessed at http://www.cochranelibrary.com on November 29, 2016.
- Khoueiry G, Abi Rafeh N, Sullivan E, et al. Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials. Heart & Lung. 2013;42(4):251-256.
- Kotwal S, Jun M, Sullivan D, et al. Omega 3 fatty acids and cardiovascular outcomes: systematic review and meta-analysis. Circulation Cardiovascular Quality and Outcomes. 2012;5(6):808-818.
- Lev-Tzion R, Griffiths AM, Leder O, et al. Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn’s disease. Cochrane Database of Systematic Reviews. 2014;(2):CD006320. Accessed at http://www.cochranelibrary.com on December 5, 2016.
- Liu A, Ji J. Omega-3 essential fatty acids therapy for dry eye syndrome: a meta-analysis of randomized controlled studies. Medical Science Monitor. 2014;20:1583-1589.
- Mazereeuw G, Lanctôt KL, Chau SA, et al. Effects of ω-3 fatty acids on cognitive performance: a meta-analysis. Neurobiology of Aging. 2012;33(7):1482.e17-29.
- Miller BJ, Murray L, Beckmann MM, et al. Dietary supplements for preventing postnatal depression. Cochrane Database of Systematic Reviews. 2013;(10):CD009104. Accessed at http://www.cochranelibrary.co on November 28, 2016.
- Mocking RJ, Harmsen I, Assies J, et al. Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Translational Psychiatry. 2016;6:e756.
- Oliver C, Watson H. Omega-3 fatty acids for cystic fibrosis. Cochrane Database of Systematic Reviews. 2016;(1):CD002201. Accessed at http://www.cochranelibrary.com on November 29, 2016.
- Parker HM, Johnson NA, Burdon CA, et al. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. Journal of Hepatology. 2012;56(4):944-951.
- Pirillo A, Catapano AL. Update on the management of severe hypertriglyceridemia—focus on free fatty acid forms of omega-3. Drug Design, Development and Therapy. 2015;9:2129-2137.
- Rayapudi S, Schwartz SG, Wang X, et al. Vitamin A and fish oils for retinitis pigmentosa. Cochrane Database of Systematic Reviews. 2013;(12):CD008428. Accessed at http://www.cochranelibrary.com on December 5, 2016.
- Raz R, Gabis L. Essential fatty acids and attention-deficit–hyperactivity disorder: a systematic review. Developmental Medicine and Child Neurology. 2009;51(8):580-592.
- Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. International Review of Psychiatry. 2006;18(2):155-172.
- Scherer DJ, Nicholls SJ. Lowering triglycerides to modify cardiovascular risk: will icosapent deliver? Vascular Health and Risk Management. 2015;11:203-209.
- Stoffers J, Völlm BA, Rücker G, et al. Pharmacological interventions for borderline personality disorder. Cochrane Database of Systematic Reviews. 2010;(6):CD005653. Accessed at http://www.cochranelibrary.com on November 29, 2016.
- Turner D, Steinhart AH, Griffiths AM. Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis. Cochrane Database of Systematic Reviews. 2007;(3):CD006443 [edited 2008]. Accessed at http://www.cochranelibrary.coon December 5, 2016.
- U.S. Department of Health and Human Services and U.S. Department of Agriculture. Dietary Guidelines for Americans: 2015–2020. 8th ed. Health.gov Web site. Accessed at https://health.gov/dietaryguidelines/2015/guidelines/ on December 5, 2016.
- U.S. Food and Drug Administration and U.S. Environmental Protection Agency. Eating Fish: What Pregnant Women and Parents Should Know. U.S. Food and Drug Administration Web site. Accessed at https://www.fda.gov/food/foodborneillnesscontaminants/metals/ucm393070.htm on December 5, 2016.
- Villani AM, Crotty M, Cleland LG, et al. Fish oil administration in older adults: is there potential for adverse events? A systematic review of the literature. BMC Geriatrics. 2013;13:41.
- Wen YT, Dai JH, Gao Q. Effects of omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: a meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases. 2014;24(5):470-475.
- Yassine HN, Braskie MN, Mack WJ, et al. Association of docosahexaenoic acid supplementation with Alzheimer disease stage in apolipoprotein E ε4 carriers: a review. JAMA Neurology. 2017;74(3):339-347.
- Zhang M, Picard-Deland E, Marette A. Fish and marine omega-3 polyunsaturated fatty acid consumption and incidence of type 2 diabetes: a systematic review and meta-analysis. International Journal of Endocrinology. 2013;2013:501015.
- Zheng J, Huang T, Yu Y, et al. Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies. Public Health Nutrition. 2012;15(4):725-737.
- Zheng T, Zhao J, Wang Y, et al. The limited effect of omega-3 polyunsaturated fatty acids on cardiovascular risk in patients with impaired glucose metabolism: a meta-analysis. Clinical Biochemistry. 2014;47(6):369-377.
NCCIH thanks D. Craig Hopp, Ph.D., and David Shurtleff, Ph.D., NCCIH, for their contributions to the 2018 update of this publication.
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