Understanding and Restoring Whole Joint Health in Pain Management: An NIH HEAL Initiative Workshop

Date: July 25, 2023 - 10:00 a.m. ET to July 26, 2023 5:00 p.m. ET

Virtual

Understanding and Restoring Whole Joint Health in Pain Management

This Helping to End Addiction Long-term^® Initiative, or NIH HEAL Initiative^®, workshop examined the current literature on joint pain research and identified critical knowledge gaps to gain a comprehensive understanding of the whole joint, including the contributions of various articular and periarticular tissue pathologies that lead to pain in different types of joints. In addition, the workshop explored manipulations and interventions that may help to restore whole joint health. Of particular interest, workshop participants examined the relationships and interactions among the different tissue components of joints, including myofascial tissues, and their contributions to and impact on reducing pain by preserving and restoring joint health and function. Five scientific sessions and a final discussion session covered structural changes in joints, mechanisms of whole joint pathology, differences among joint types and joint pain populations, interventions to address joint pain and disease, and emerging technologies that can be leveraged to advance scientific understanding of joints as complex “organs.” The intended audience was interested scientists, clinicians, as well as patients, advocates, and other interested stakeholders.

Use this hashtag to share on Twitter: #WholeJointHealthMtg

View the executive meeting summary [142 KB PDF]
View the full meeting summary [257 KB PDF]
View the program book [1.7 MB PDF]

Watch the event:

Tuesday, July 25

Wednesday, July 26

Agenda

Tuesday, July 25

10:00–10:15 a.m. | Welcome and NIH HEAL Overview

Rebecca Baker, Ph.D., National Institutes of Health (NIH) Helping to End Addiction Long-term^®Initiative, or NIH HEAL Initiative^®, Director

10:15-10:45 a.m. | Opening Remarks

Helene M. Langevin, M.D., National Center for Complementary and Integrative Health (NCCIH) Director
Lindsey Criswell, M.D., M.P.H., D.Sc., National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Director

10:45 a.m.–12:30 p.m. | Session One: Structural and Mechanical Factors in Joint Pain

Chair: Rebecca Lenzi, Ph.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Co-Chair: Melissa Ghim, Ph.D., National Institute of Dental and Craniofacial Research (NIDCR)
External Co-Chair: Richard Loeser, M.D., University of North Carolina (UNC)
- Speakers
  - Richard Loeser, M.D., UNC
  - Hai Yao, Ph.D., Clemson University/Medical University of South Carolina
  - Ali Guermazi, M.D., Ph.D., Boston University
  - David Walsh, F.R.C.P., Ph.D., University of Nottingham
- Panelist Comments for Additional Perspectives
  - Farshid Guilak, Ph.D., Washington University School of Medicine, St. Louis
  - Joel Block, M.D., Rush University
  - Thomas Clemens, Ph.D, University of Maryland
  - Laura Stone, Ph.D., University of Minnesota (UMN)
  - Tristan Maerz, Ph.D., University of Michigan
- Panel Discussion
- Questions and Answers from the Zoom and VideoCast Audiences

12:30–1:30 p.m. | LUNCH

1:30–3:15 p.m. | Session Two: Mechanisms of Whole Joint Pathology

Chair: John Williams, Ph.D., National Institute on Aging
Co-Chair: Wen Chen, Ph.D., NCCIH
External Co-Chair: Martin Lotz, Ph.D., Scripps Research
- Speakers
  - Carla Stecco, M.D., The University of Padua
  - Anne-Marie Malfait, M.D., Ph.D., Rush University
  - Kelsey Collins, Ph.D., University of California, San Francisco (UCSF)
  - Martin Lotz, M.D., Scripps Research
- Panelist Comments for Additional Perspectives
  - Dana Orange, M.D., Rockefeller University
  - Alisa Johnson, L.M.T., Ph.D., University of Florida
  - Marcas Bamman, Ph.D., The Florida Institute for Human and Machine Cognition
  - Tuhina Neogi, M.D., Ph.D., Boston University
  - Nick Willet, Ph.D., University of Oregon
- Panel Discussion
- Questions and Answers from the Zoom and VideoCast Audiences

3:15–3:30 p.m. | BREAK

3:30–5:15 p.m. | Session Three: Differences Among Joint Types and Joint Pain Populations

Chair: Melissa Ghim, Ph.D., NIDCR
Co-Chair: Miguel Ossandon, Ph.D., National Cancer Institute
External Co-Chair: Clair A. Francomano, M.D., Indiana University
- Speakers:
  - Clair A. Francomano, M.D., Indiana University
  - Beth Winkelstein, Ph.D., University of Pennsylvania
  - Vijay Goel, Ph.D., University of Toledo
  - Amanda Nelson, M.D., M.S.C.R., Rh.M.S.U.S., UNC
- Panelist Comments for Additional Perspectives on Presented Talks
  - Leslie Russek, P.T., D.P.T., Ph.D., Clarkson University
  - Anna Shmagel, M.D., M.Sc., Medical Director, AbbVie Immunology Clinical Development
  - Kendi Hensel, D.O., Ph.D., Texas College of Osteopathic Medicine
  - Laura Cappelli, M.D., Johns Hopkins University
  - Gary Bouloux, M.D., Emory University
- Panel Discussion
- Questions and Answers from the Zoom and VideoCast Audiences

5:15–5:30 p.m. | Concluding Remarks

Emmeline Edwards, Ph.D., NCCIH, Division of Extramural Research Director

5:30 p.m. | ADJOURN

Wednesday, July 26

10:00–10:15 a.m. | Welcome Back

Walter Koroshetz, M.D., National Institute of Neurological Disorders and Stroke (NINDS) Director

10:15 a.m.–Noon | Session Four: Interventions To Address Joint Pain and Disease

Chair: Alex Tuttle, Ph.D., NCCIH
Co-Chair: Michael Oshinsky, Ph.D., NINDS
External Co-Chair: Kathleen Sluka, P.T., Ph.D., University of Iowa
- Speakers:
  - Kathleen Sluka, P.T., Ph.D., University of Iowa
  - Dan Rhon, D.P.T., D.S.C., Ph.D., Baylor University
  - Stephen Messier, Ph.D., Wake Forest University
  - Preeti Raghavan, M.D., Johns Hopkins Medicine
- Panelist Comments for Additional Perspectives
  - Gunnar Brolinson, D.O., Edward Via College of Osteopathic Medicine
  - Katie Butera, D.P.T., Ph.D., University of Delaware
  - Gert Bronfort, D.C., Ph.D., UMN
  - Christine Goertz, D.C., Ph.D., Duke University
  - Brian Noehren, P.T., Ph.D., University of Kentucky
- Panel Discussion
- Questions and Answers from the Zoom and VideoCast Audiences

Noon–1:00 p.m. | LUNCH

1:00–2:45 p.m. | Session Five: Emerging Technologies and Models

Chair: Qi Duan, Ph.D., National Institute of Biomedical Imaging and Bioengineering
Co-Chair: Julia Bachman, Ph.D., NINDS
External Co-Chair: Riccardo Lattanzi, Ph.D., New York University (NYU)
- Speakers:
  - Riccardo Lattanzi, Ph.D., NYU
  - Valentina Pedoia, Ph.D., UCSF
  - Kevin Koch, Ph.D., Medical College of Wisconsin
  - Ziying Yin, Ph.D., Mayo Clinic
- Panelist Comments for Additional Perspectives
  - Scott Banks, Ph.D., University of Florida
  - Feliks Kogan, Ph.D., Stanford University
  - Lucia Cevidanes, D.D.S., Ph.D., University of Michigan
  - Siddhartha Sikdar, Ph.D., George Mason University
- Panel Discussion
- Questions and Answers from the Zoom and VideoCast Audiences

2:45–3:15 p.m. | BREAK

3:15–4:35 p.m. | Session Six: General Discussion

Chair: Helene M. Langevin, M.D., NCCIH
Co-Chair: Gayle Lester, Ph.D., NIAMS
- Open Discussion of Challenges and Opportunities
- Chair and Co-Chair Summary

4:35–4:55 p.m. | Summary and Concluding Remarks

Alex Tuttle, Ph.D., NCCIH, Program Director and Workshop Lead

4:55 p.m. | ADJOURN

Planning Committee

NCCIH

Wen Chen, Ph.D.
Helene M. Langevin, M.D.
Alex Tuttle, Ph.D.

NCI

Miguel Ossandon, Ph.D.

NIA

Devon Oskvig, Ph.D.
John Williams, Ph.D.,

NIAMS

Rebecca Lenzi, Ph.D.
Gayle Lester, Ph.D.

NIBIB

Qi Duan, Ph.D.

NIDCR

Melissa Ghim, Ph.D.

NINDS

Michael Oshinsky, Ph.D.
Julia Bachman, Ph.D.