Examples of NCCIH-Funded Natural Products Clinical Trials

The research projects listed below are examples of studies supported by NCCIH for natural product clinical trials over the past 10 years.

K24

Patient-Oriented Research in Arginine Deficiency Syndromes
Emory University
Morris, Claudia R
1K24AT009893-01

P01

Chinese Herbal Medicine as a Novel Paradigm for Cancer Chemotherapy
Yale University
Cheng, Yung-chi
1P01CA154295-01A1

R01

REVIVE—Resveratrol To Enhance Vitality and Vigor in Elders
University of Florida
Anton, Stephen D
1R01AT007564-01A1

Clinical & Metabolic Effects of Altering N-3 & N-6 Fatty Acids in Migraine (RCT)
University of North Carolina at Chapel Hill
Mann, John Douglas
1R01AT007813-01A1

Efficacy of Open-Label Placebo, Double-Blind Placebo, and Peppermint Oil in IBS
Beth Israel Deaconess Medical Center
Lembo, Anthony J
1R01AT008573-01A1

Role of PUFA-Gene Interactions in Health Disparities
Wake Forest University Health Sciences
Chilton, Floyd H
1R01AT008621-01A1

Metals in the Trial To Assess Chelation Therapy 2 (TACT2M)
Mount Sinai Medical Center (Miami Beach)
Lamas, Gervasio A
1R01AT009273-01

Inositol Supplementation To Treat Reproductive and Metabolic Dysfunction in Polycystic Ovary Syndrome: A Double Blind RCT (INSUPP-PCOS)
Pennsylvania State University Hershey Medical Center
Legro, Richard S
1R01AT009484-01A1

Road to Discovery for Combination Probiotic BB-12 With LGG in Treating Autism Spectrum Disorder
University of Texas Health Science Center at Houston
Rhoads, Jon Marc
1R01HD095158-01

Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
University of Michigan at Ann Arbor
Harris, Richard E
1R01AT010381-01A1

Biological Signature and Safety of an Immunomodulatory Probiotic Intervention of Veterans With PTSD
University of Colorado Denver
Brenner, Lisa A
1R01AT010005-01A1

Analgesic and Subjective Effects of Terpenes Administered Alone and in Combination With THC: Potential THC- and Opioid-Sparing Effects of Myrcene and ß-Caryophyllene
University of California Los Angeles
Cooper, Ziva D
1R01AT010762-01

R21

Beneficial Effects of Quercetin in COPD—A Preliminary Clinical Trial
University of Michigan at Ann Arbor
Sajjan, Umadevi Sivanappa
1R21AT007357-01

Icariin To Prevent Corticosteroid-Related Memory Changes
University of Texas Southwestern Medical Center
Brown, E Sherwood
1R21AT007869-01

Phased Exploratory Clinical Studies of Harpagophytum procumbens’ Impact Upon the Biological Signature of Inflammatory Osteoarthritis
University of Missouri Kansas City
Gerkovich, Mary M
1R21AT009086-01

Role of Zinc in HIV Inflammation
Case Western Reserve University
McComsey, Grace A
1R21AT009153-01

R33

Optimization of Blood Levels of 25(OH)-Vitamin D in African Americans
Louisiana State Univ Health Science Center Shreveport
Jain, Sushil K
1R33AT010637-01A1

R34

Effect of Lactobacillus GG on Gut Permeability and Microbiome in VLBW Neonates
University of Maryland, Baltimore
Fasano, Alessio
1R34AT006945-01

Safety and Effect of L. reuteri on Biomarkers of Inflammation in Healthy Infants
University of Texas Health Science Center at Houston
Rhoads, Jon Marc
1R34AT006727-01A1

Curcuma longa L. in Rheumatoid Arthritis (CLaRA): Clinical Planning Study
University of Arizona
Funk, Janet L
1R34AT007837-01

R43

The First Pomegranate Seed Oil–Containing Medical Food for Gut and Immune Health
Biotherapeutics, Inc.
Hontecillas, Raquel
1R43AT010991-01

R61

Identifying Biological Signatures of N-Acetylcysteine for Non-Suicidal Self-Injury in Adolescents
University of Minnesota
Cullen, Kathryn Regan
1R61AT009995-01

Impact of Quercetin on Inflammatory and Oxidative Stress Markers in COPD
Temple University of the Commonwealth
Sajjan, Umadevi Sivanappa
1R61AT009991-01

Prebiotic Treatment in People With Schizophrenia
University of Maryland, Baltimore
Buchanan, Robert W
1R61AT009990-01

Development of Pregnenolone as a Treatment for Depression
University of Texas Southwestern Medical Center
Brown, E Sherwood
1R61AT009625-01A1

31P-MRS and Resting State Functional Connectivity Analysis of the Effects of 5-Hydroxytryptophan and Creatine for Antidepressant Augmentation in Patients With SSRI/SNRI-Resistant Major Depressive Disorder
University of Utah
Kious, Brent Michael
1R61AT010636-01A1

U01

Preparation for GTP Long-Term Clinical Study on Bone Health
Texas Tech University Health Sciences Center
Shen, Chwan-Li L
1U01AT006691-01A1

Creatine Safety and Efficacy in HD: Coordination and Statistical Center
University of Rochester
Schifitto, Giovanni
1U01AT008197-01

U19

Influence of Dietary Botanical Supplements on Biological and Behavioral Resilience
Icahn School of Medicine at Mount Sinai
Pasinetti, Giulio Maria
1U19AT010835-01

Spirulina Oral Supplement for Enhancing Host Resilience to Virus Infection
University of Mississippi
Khan, Ikhlas Ahmad
1U19AT010838-01

UG3

Omega-3 Fatty Acids for MDD With High Inflammation: A Personalized Approach
Emory University
Rapaport, Mark Hyman
1UG3AT008857-01

UH3

Trial To Assess Chelation Therapy 2- TACT2 CCC
Mount Sinai Medical Center (Miami Beach)
Lamas, Gervasio A
5UH3AT009149-03