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Alzheimer’s Disease at a Glance

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Researchers have explored many complementary health approaches for preventing or slowing dementia, including Alzheimer’s disease. Currently, there is no strong evidence that any complementary health approach can prevent cognitive impairment.

What the Science Says

Following are some of the complementary health approaches that have been studied in recent years.

  • Fish Oil/Omega-3s. Among the nutritional and dietary factors studied to prevent cognitive decline in older adults, the most consistent positive research findings are for omega-3 fatty acids, often measured as how much fish people ate. However, taking omega-3 supplements did not have any beneficial effects on the cognitive functioning of older people without dementia.
  • Ginkgo. An NCCIH-funded study of the well-characterized ginkgo supplement EGb-761 found that it didn’t lower the incidence of dementia, including Alzheimer's disease, in older adults. Further analysis of the same data showed that ginkgo did not slow cognitive decline, lower blood pressure, or reduce the incidence of hypertension. In this clinical trial, known as the Ginkgo Evaluation of Memory study, researchers recruited more than 3,000 volunteers age 75 and older who took 240 mg of ginkgo daily. Participants were followed for an average of approximately 6 years.
  • B-vitamins. Results of short-term studies suggest that B-vitamin supplements do not help cognitive functioning in adults age 50 or older with or without dementia. The vitamins studied were B12, B6, and folic acid, taken alone or in combination.
  • Curcumin, which comes from turmeric, has anti-inflammatory and antioxidant properties that might affect chemical processes in the brain associated with Alzheimer’s disease, laboratory studies have suggested. However, the few clinical trials (studies done in people) that have looked at the effects of curcumin on Alzheimer’s disease have not found a benefit.
  • Melatonin. People with dementia can become agitated and have trouble sleeping. Supplements of melatonin, which is a naturally occurring hormone that helps regulate sleep, are being studied to see if they improve sleep in some people with dementia. However, in one study researchers noted that melatonin supplements may worsen mood in people with dementia.
  • For caregivers, taking a mindfulness meditation class or a caregiver education class reduced stress more than just getting time off from providing care, a small, 2010 NCCIH-funded study showed.

Side Effects and Risks

  • Don’t use complementary approaches as a reason to postpone seeing a health care provider about memory loss. Treatable conditions, such as depression, bad reactions to medications, or thyroid, liver, or kidney problems, can cause memory impairment.
  • Keep in mind that although many dietary supplements (and some prescription drugs) come from natural sources, “natural” does not always mean “safe.”
  • Some dietary supplements have been found to interact with medications, whether prescription or over-the-counter. For example, the herbal supplement St. John’s wort interacts with many medications, making them less effective. Your health care provider can advise you.

For More Information

NCCIH Clearinghouse

The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.

Toll-free in the U.S.: 1-888-644-6226

Telecommunications relay service (TRS): 7-1-1

Website: https://nccih.nih.gov/

Email: info@nccih.nih.gov (link sends email)

Know the Science

NCCIH and the National Institutes of Health (NIH) provide tools to help you understand the basics and terminology of scientific research so you can make well-informed decisions about your health. Know the Science features a variety of materials, including interactive modules, quizzes, and videos, as well as links to informative content from Federal resources designed to help consumers make sense of health information.

Explaining How Research Works (NIH)

Know the Science: 9 Questions To Help You Make Sense of Health Research

Understanding Clinical Studies (NIH)

PubMed®

A service of the National Library of Medicine, PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed.

Website: https://pubmed.ncbi.nlm.nih.gov/

This publication is not copyrighted and is in the public domain. Duplication is encouraged.

NCCIH has provided this material for your information. It is not intended to substitute for the medical expertise and advice of your health care provider(s). We encourage you to discuss any decisions about treatment or care with your health care provider. The mention of any product, service, or therapy is not an endorsement by NCCIH.

Last Updated: June 2019