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Stress is a physical and emotional reaction that people experience as they encounter challenges in life. When you’re under stress, your body reacts by releasing hormones that produce the “fight-or-flight” response. Your heart rate, breathing rate, and blood pressure go up, your muscles tense, and you sweat more. Occasional stress is a normal coping mechanism. However, long-term stress (also called chronic stress) may contribute to or worsen a range of health problems including digestive disorders, headaches, sleep disorders, and other symptoms. Stress may worsen asthma and has been linked to depression, anxiety, and other mental illnesses.

There is no drug to cure stress. But we do have access to a built-in “stress reset button.” It’s called the relaxation response. In contrast to the stress response, the relaxation response slows the heart rate, lowers blood pressure, and decreases oxygen consumption and levels of stress hormones.

Press Reset on Stress  Press Reset on Stress, [1.21 MB PDF] 

Some people use psychological and physical approaches, such as yoga, mindfulness, or relaxation techniques, to release tension and to counteract the ill effects of stress.

Recognize When You Need More Help

If you are struggling to cope, or if the symptoms of your stress won’t go away, it may be time to talk to a professional. 

If you are in immediate distress or are thinking about hurting yourself, call, text, or chat 988. This 3-digit number will route you to the 988 Suicide & Crisis Lifeline, which is now active across the United States. The Lifeline provides 24-hour, confidential support to anyone in suicidal crisis or emotional distress. 

If you or someone you know has a mental illness, is struggling emotionally, or has concerns about their mental health, there are ways to get help. Read more about getting help.

The Bottom Line

Relaxation Techniques

Creating the relaxation response through the use of relaxation techniques can counteract the negative effects of stress. There is evidence that relaxation techniques can reduce blood pressure, inflammatory cytokines, and oxidative stress, as well as improve glycemic control in people with type 2 diabetes.

Relaxation techniques often combine breathing and focused attention on pleasing thoughts and images to calm the mind and the body. Some examples of relaxation techniques are autogenic training, biofeedback, deep breathing, guided imagery, progressive relaxation, and self-hypnosis. 

  • Deep Breathing 
    • Studies have shown that slow, deep breathing (also called diaphragmatic breathing) exercises may modestly lower blood pressure and reduce levels of cortisol (a main stress hormone in the body). 
    • A 2019 review of 3 studies, with a total of 880 participants, found preliminary evidence suggesting that diaphragmatic breathing exercises may help to reduce stress. Promising positive changes were seen in mental health self-evaluations and in certain physical measures, such as cortisol levels and blood pressure.
    • There is evidence that deep breathing reduces glycemia (the concentration of glucose or sugar in the blood) in people with type 2 diabetes, which may make it a useful addition to standard care for this condition.
  • Biofeedback
    • A 2018 review found that relaxation therapies and biofeedback might be helpful for reducing blood pressure, but only weak recommendations were made for their use because the quality of data from the 29 studies ranged from low to very low.
    • Several studies have looked at heart rate variability (HRV) biofeedback. One review of 24 studies involving a total of 484 participants found that HRV biofeedback is helpful for reducing self-reported stress and anxiety, and the researchers saw it as a promising approach with further development of wearable devices such as a fitness tracker.
  • Progressive Muscle Relaxation
    • Studies have shown that progressive muscle relaxation may produce stress-alleviating effects, as well as have a positive effect on anxiety and depression in some people.
    • A 2016 study showed that progressive muscle relaxation can decrease blood pressure during pregnancy.

Meditation and Mindfulness Practices

  • Mindfulness
    • Current scientific evidence suggests that mindfulness meditation—a practice that cultivates abilities to maintain focused and clear attention and develop increased awareness of the present—may help reduce symptoms of stress, including anxiety and depression, and may help improve sleep.
      • A 2022 study found that participants who practiced mindfulness had a significant reduction in perceived stress and anxiety levels, as well as an improved balance of some key mediators of inflammatory states. 
      • A 2021 study conducted in university students found that mindfulness was associated with low levels of psychological distress and that a brief mindfulness-based intervention was useful to reduce distress measures in this population.
      • A 2019 review of 18 studies found moderately strong evidence that mindfulness meditation interventions significantly improved sleep quality in a variety of groups of people with sleep disturbances.
      • A 2018 review of scientific literature that examined mindfulness-based programs targeting workplace stress or work engagement found that mindfulness-based interventions may be a promising avenue for improving stress indicators in the body. 
  • Meditation
    • A 2017 review of research on meditation and physiological markers of stress that included eight studies of focused attention meditation found that this type of meditation reduced blood pressure and cortisol levels.
    • Results of a 2009 NCCIH-funded trial involving 298 university students suggest that practicing Transcendental Meditation (TM) may lower the blood pressure of people at increased risk of developing high blood pressure. The findings also suggested that practicing meditation can help with psychological distress, anxiety, depression, anger/hostility, and coping ability. 
    • A literature review and scientific statement from the American Heart Association suggest that evidence supports the use of TM to lower blood pressure. However, the review indicates that it’s uncertain whether TM is truly superior to other meditation techniques in terms of lowering blood pressure because there are few head-to-head studies.
    • Clinical practice guidelines issued in 2014 by the Society for Integrative Oncology recommend meditation as supportive care to reduce stress, anxiety, depression, and fatigue in patients treated for breast cancer. Stress management, yoga, massage, music therapy, energy conservation, and meditation are recommended for stress reduction, anxiety, depression, fatigue, and quality of life.


  • Some but not all studies of yoga for stress management have shown improvements in physical or psychological measures related to stress.
    • A 2020 review of 12 studies of a variety of types of yoga for stress management in healthy adults found beneficial effects of yoga on measures of perceived stress.
    • Of 17 older studies of yoga for stress management included in a 2014 review, 12 showed improvements in physical or psychological measures related to stress.
    • A 2018 study involving 90 participants investigated the effects of 8- and 16-week gym yoga on stress and psychological health. The study found that when compared to the control group, those who practiced yoga showed significant decreases in stress and anxiety, improvements in general psychological health, and increases in well-being.
    • 2017 clinical practice guidelines issued by the American Cancer Society on the evidence-based use of integrative therapies during and after breast cancer treatment recommend yoga for anxiety/stress reduction. 


  • Meditation and mindfulness practices usually are considered to have few risks. However, few studies have examined these practices for potentially harmful effects, so it isn’t possible to make definite statements about safety.
  • Relaxation techniques are generally considered safe for healthy people. In most research studies, there have been no reported negative side effects. However, occasionally, people report negative experiences such as increased anxiety, intrusive thoughts, or fear of losing control.
  • There have been rare reports that certain relaxation techniques might cause or worsen symptoms in people with epilepsy or certain psychiatric conditions, or with a history of abuse or trauma.
  • Yoga is generally considered a safe form of physical activity for healthy people when performed properly, under the guidance of a qualified instructor. However, as with other forms of physical activity, injuries can occur. The most common injuries are sprains and strains, and the parts of the body most commonly injured are the knee or lower leg. Serious injuries are rare. The risk of injury associated with yoga is lower than that for higher impact physical activities. For more information on the safety of yoga, visit the National Center for Complementary and Integrative Health’s fact sheet, Yoga: What You Need To Know.
  • If you have high blood pressure, it’s important to follow the treatment plan prescribed by your health care provider. Following your treatment plan is important because it can prevent or delay serious complications of high blood pressure. If you’re considering a complementary or integrative approach for your high blood pressure, discuss it with your health care provider.

NCCIH-Funded Research

Current studies funded by the National Center for Complementary and Integrative Health (NCCIH) are investigating a variety of topics related to stress, including: 

  • Exposure to stressors and the development of resilience in National Guard recruits during Basic Combat Training and their first 2 years of service. 
  • The effects of a mindfulness-based diabetes education program targeted at stress reduction on adults who have type 2 diabetes and elevated levels of distress related to their condition.
  • The effects of psychological stress, stress resilience, and mindfulness-based interventions on disease activity and symptom severity in people with rheumatoid arthritis.

For More Information

NCCIH Clearinghouse

The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.

Toll-free in the U.S.: 1-888-644-6226

Telecommunications relay service (TRS): 7-1-1


Email: (link sends email)

Know the Science

NCCIH and the National Institutes of Health (NIH) provide tools to help you understand the basics and terminology of scientific research so you can make well-informed decisions about your health. Know the Science features a variety of materials, including interactive modules, quizzes, and videos, as well as links to informative content from Federal resources designed to help consumers make sense of health information.

Explaining How Research Works (NIH)

Know the Science: How To Make Sense of a Scientific Journal Article

Understanding Clinical Studies (NIH)


A service of the National Library of Medicine, PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed.


Key References

Other References

  • American Academy of Pediatrics Section on Integrative Medicine. Mind-body therapies in children and youth. Pediatrics. 2016;138(3):e20161896.
  • Bhasin MK, Denninger JW, Huffman JC, et al. Specific transcriptome changes associated with blood pressure reduction in hypertensive patients after relaxation response training. Journal of Alternative and Complementary Medicine. 2018;24(5):486-504.
  • Creswell JD. Mindfulness interventions. Annual Review of Psychology. 2017;68:491-516.
  • Farias M, Maraldi E, Wallenkampf KC, et al. Adverse events in meditation practices and meditation-based therapies: a systematic review. Acta Psychiatrica Scandinavica. 2020;142(5):374-393.
  • Goessl VC, Curtiss JE, Hofmann SG. The effect of heart rate variability biofeedback training on stress and anxiety: a meta-analysis. Psychological Medicine. 2017;47(15):2578-2586.
  • Greenlee H, DuPont-Reyes MJ, Balneaves LG, et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA: A Cancer Journal for Clinicians. 2017;67(3):194-232.
  • Heckenberg RA, Eddy P, Kent S, et al. Do workplace-based mindfulness meditation programs improve physiological indices of stress? A systematic review and meta-analysis. Journal of Psychosomatic Research. 2018;114:62-71.
  • Hopper SI, Murray SL, Ferrara LR, et al. Effectiveness of diaphragmatic breathing for reducing physiological and psychological stress in adults: a quantitative systematic review. JBI Database of Systematic Reviews and Implementation Reports. 2019;17(9):1855-1876.
  • Ma X, Yue Z-Q, Gong Z-Q, et al. The effect of diaphragmatic breathing on attention, negative affect and stress in healthy adults. Frontiers in Psychology. 2017;8:874.
  • Maddux RE, Daukantaité D, Tellhed U. The effects of yoga on stress and psychological health among employees: an 8- and 16-week intervention study. Anxiety, Stress, and Coping. 2018;31(2):121-134.
  • Martarelli D, Cocchioni M, Scuri S, et al. Diaphragmatic breathing reduces postprandial oxidative stress. Journal of Alternative and Complementary Medicine. 2011;17(7):623-628.
  • MedlinePlus. Stress. Accessed at on April 12, 2022.
  • Ng TKS, Fam J, Feng L, et al. Mindfulness improves inflammatory biomarker levels in older adults with mild cognitive impairment: a randomized controlled trial. Translational Psychiatry. 2020;10(1):21.
  • Nidich SI, Rainforth MV, Haaga DAF, et al. A randomized controlled trial on effects of the Transcendental Meditation program on blood pressure, psychological distress, and coping in young adults. American Journal of Hypertension. 2009;22(12):1326-1331. 
  • Niu J-F, Zhao X-F, Hu H-T, et al. Should acupuncture, biofeedback, massage, qi gong, relaxation therapy, device-guided breathing, yoga and tai chi be used to reduce blood pressure?: Recommendations based on high-quality systematic reviews. Complementary Therapies in Medicine. 2019;42:322-331.
  • Sharma M. Yoga as an alternative and complementary approach for stress management: a systematic review. Journal of Evidence-Based Complementary and Alternative Medicine. 2014;19(1):59-67.
  • Sousa GM, Lima-Araújo GL, Araújo DB, et al. Brief mindfulness-based training and mindfulness trait attenuate psychological stress in university students: a randomized controlled trial. BMC Psychology. 2021;9(1):21.
  • Toussaint L, Nguyen QA, Roettger C, et al. Effectiveness of progressive muscle relaxation, deep breathing, and guided imagery in promoting psychological and physiological states of relaxation. Evidence-Based Complementary and Alternative Medicine. 2021;2021:5924040.
  • Twal WO, Wahlquist AE, Balasubramanian S. Yogic breathing when compared to attention control reduces the levels of pro-inflammatory biomarkers in saliva: a pilot randomized controlled trial. BMC Complementary and Alternative Medicine. 2016;16:294.
  • Van Dam NT, van Vugt MK, Vago DR, et al. Mind the hype: a critical evaluation and prescriptive agenda for research on mindfulness and meditation. Perspectives on Psychological Science. 2018;13(1):36-61.
  • Wang F, Szabo A. Effects of yoga on stress among healthy adults: a systematic review. Alternative Therapies in Health and Medicine. 2020;26(4):AT6214.
  • Yeh GY, Horwitz R. Integrative medicine for respiratory conditions: asthma and chronic obstructive pulmonary disease. Medical Clinics of North America. 2017;101(5):925-941.


Additional Resources

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NCCIH has provided this material for your information. It is not intended to substitute for the medical expertise and advice of your health care provider(s). We encourage you to discuss any decisions about treatment or care with your health care provider. The mention of any product, service, or therapy is not an endorsement by NCCIH.

Last Updated: April 2022