Cancer and Complementary Health Approaches: What You Need To Know
Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts of the body. Although cancer is the second leading cause of death in the United States, people with cancer are living longer because of improvements in early detection and treatment. About two out of every three people in the United States diagnosed with cancer will live at least 5 years after diagnosis.
For more information about cancer, visit the National Cancer Institute (NCI) website.
About Complementary Health Approaches
Complementary health approaches are a group of diverse medical and health care systems, practices, and products whose origins come from outside of mainstream medicine. They include such products and practices as herbal supplements, other dietary supplements, meditation, spinal manipulation, and acupuncture.
Complementary approaches can be classified by their primary therapeutic input (how the therapy is taken in or delivered), which may be:
- Nutritional (e.g., special diets, dietary supplements, herbs, probiotics, and microbial-based therapies)
- Psychological (e.g., meditation, hypnosis, music therapies, relaxation therapies)
- Physical (e.g., acupuncture, massage, spinal manipulation)
- Combinations such as psychological and physical (e.g., yoga, tai chi, dance therapies, some forms of art therapy) or psychological and nutritional (e.g., mindful eating)
This publication looks at complementary health approaches that have been studied for cancer prevention, treatment of the disease, or symptom management, including what the science says about their effectiveness and any concerns that have been raised about their safety.
Incorporating Complementary Health Approaches Into Cancer Care
The Society for Integrative Oncology has issued evidence-based clinical practice guidelines for health care providers to consider when incorporating complementary health approaches in the care of people with cancer.
The guidelines state that, when used in addition to conventional therapies, some of these approaches help to control symptoms and enhance patients’ well-being. The guidelines warn, however, that unproven methods shouldn’t be used in place of conventional treatment because delayed treatment of cancer reduces the likelihood of a remission or cure.
Complementary Health Approaches for Cancer Symptoms and Treatment Side Effects
Some complementary health approaches may help people manage cancer symptoms or the side effects of treatment. However, some approaches may interfere with conventional cancer treatment or have other risks. People who have been diagnosed with cancer should consult their health care providers before using any complementary health approach.
Psychological and Physical Approaches
- Several evaluations of the evidence have concluded that acupuncture can help manage treatment-related nausea and vomiting in people with cancer.
- A 2020 combined analysis of 14 studies (920 participants) found that acupuncture was associated with significant reductions in cancer pain, both in studies where acupuncture was compared with sham (simulated) acupuncture and in studies where acupuncture was compared with no treatment. In two studies, the use of acupuncture or acupressure in addition to pain medicine helped people with cancer reduce their dose of pain medicine.
- A 2018 review of 10 studies (1,327 participants) showed that acupuncture may be more helpful than sham acupuncture or usual care in relieving cancer-related fatigue.
- Research on the effects of acupuncture on cancer-related hot flashes is limited.
- Complications from acupuncture are rare, as long as the acupuncturist uses sterile needles and proper procedures. Chemotherapy and radiation therapy weaken the immune system, so it’s especially important for acupuncturists to follow strict clean-needle procedures to reduce the risk of infection when treating people with cancer.
- Hypnosis may be helpful for pain caused by cancer itself or by procedures used in cancer care, for nausea and vomiting in people with breast cancer, and for anxiety and distress around surgical and medical procedures in both adults and children. It may also be helpful for hot flashes in women with breast cancer.
- Hypnosis is a safe technique when practiced by a trained, experienced, licensed health care provider.
- Massage therapy, with or without aromatherapy (the use of essential oils), has been used to attempt to relieve pain, anxiety, and other symptoms in people with cancer. However, there is only limited evidence on whether it is beneficial.
- A 2021 review of 13 studies (1,100 participants) of various manual therapies, including but not limited to massage therapy, provided evidence for benefits on pain, physical function, and global well-being but not fatigue, nausea, anxiety, or depression. These results should be interpreted cautiously because a variety of different manual therapies and measurement techniques were included and because some studies included small numbers of participants or were of low quality.
- A 2016 evaluation of 19 studies (more than 1,200 participants) of massage for people with cancer found some evidence that massage might help with pain and anxiety, but the quality of the evidence was very low, and findings were not consistent.
- Massage therapists may need to modify their usual techniques when working with people with cancer; for example, they may have to use less pressure than usual in areas that are sensitive because of cancer or cancer treatments.
Mindfulness-Based Stress Reduction
- A 2020 review of 26 studies (3,476 participants) of people with various types of cancer showed that those who participated in mindfulness-based interventions had less anxiety, depression, fatigue, and stress, and a better quality of life than those who did not participate in mindfulness-based interventions.
- Mindfulness and other forms of meditation are generally considered to be safe for healthy people. However, they may need to be modified to make them safe and comfortable for people with some health conditions. For example, if you can’t sit still comfortably for long periods of time, your meditation instructor can adapt the meditation practice so that you don’t need to do this.
Tai Chi and Qigong
- A 2020 review looked at 16 studies (1,268 participants) of tai chi in women with breast cancer. Some of the studies evaluated tai chi as an alternative to conventional supportive care interventions such as aerobic exercise and cognitive behavioral therapy, and others evaluated it as an addition to conventional care. Tai chi improved fatigue when used as an addition to conventional care (two studies) but not when used as an alternative to conventional care (two studies). Tai chi improved overall quality of life when used either as an addition to conventional care (four studies) or as an alternative to conventional care (two studies).
- A 2019 review of 12 recent studies (915 participants) of qigong or tai chi for patients with various types of cancer found favorable effects on symptoms of fatigue and sleep quality that were large enough to be meaningful to patients.
- Tai chi and qigong are generally considered to be safe practices.
- A 2020 evaluation of 24 studies of yoga for women with breast cancer, involving a total of more than 1,600 participants, concluded that yoga provides small-to-moderate improvements in cancer-related fatigue and quality of life compared to interventions not involving physical activity. Therefore, it could be a supportive intervention for women with breast cancer, as an addition to standard treatment.
- A 2021 review of 26 studies of yoga-based interventions for depressive symptoms (1,486 participants) and 16 studies of yoga-based interventions for anxiety symptoms (977 participants) in people with various types of cancer found evidence that the interventions were helpful for both types of symptoms. The majority of the studies involved women with breast cancer.
- Yoga is generally considered a safe form of physical activity for healthy people when performed properly under the guidance of a qualified instructor. However, as with other forms of physical activity, injuries can occur. The most common injuries are sprains and strains. Serious injuries are rare. In studies of yoga in people with cancer, adverse events have mostly been minor. However, having an ongoing health problem such as cancer may increase the risks of doing yoga. If you have cancer, talk with your health care providers to find out whether any aspects of yoga might be unsafe for you.
- Ginger is an herb that is sold as a dietary supplement. A 2019 evaluation of 18 studies with more than 1,600 participants concluded that the evidence on whether ginger is helpful for nausea associated with cancer chemotherapy is mixed. Some studies suggested that ginger helped to control nausea, but in other studies, ginger didn’t seem to have any effect.
- People diagnosed with cancer should consult their health care providers before taking ginger or any other dietary supplement.
Complementary Health Approaches for Cancer Treatment
No complementary approach has been shown to cure cancer or cause it to go into remission. Some products or practices that have been advocated for cancer treatment may interfere with conventional cancer treatments or have other risks. If you’ve been diagnosed with cancer, you should consult your health care providers before using any complementary health approach.
The following sections discuss a few products that have been promoted as cancer treatments. You can find information on additional products at the NCI website.
- Studies on whether herbal supplements or substances derived from them might be of value in cancer treatment are in their early stages, and scientific evidence is limited. Herbal supplements may have side effects, and some may interact in harmful ways with drugs, including those used in cancer treatment.
Vitamin, Mineral, and Antioxidant Dietary Supplements
- The effects of taking vitamin and mineral dietary supplements, including antioxidant supplements, during cancer treatment are uncertain. Because these supplements might interfere with the effectiveness of chemotherapy or other cancer therapies, if you are being treated for cancer, you should discuss their use with your health care providers.
- Products called black salves have been marketed for self-treatment of a variety of skin conditions, including skin cancer. Black salves are neither safe nor effective. When used to treat a skin cancer, black salve products may not remove all of it, which may allow the cancer to spread and become more serious. Also, black salves can destroy both cancerous and healthy skin. They can cause scarring and tissue damage, which is sometimes severe and disfiguring. Most black salve research involves case studies; well-controlled clinical trials have not been conducted.
- Laetrile is another name for the natural substance amygdalin, a chemical constituent found in the pits of many fruits. A 2019 review of research on laetrile found no clinical evidence it is effective as a cancer treatment. Laetrile can have toxic effects.
Intravenous Vitamin C
- Studies on the benefit of high-dose, intravenous vitamin C use for cancer have yielded varying results. Research in people is limited; most of the evidence is based on animal and laboratory research. The evidence is mixed for intravenous vitamin C’s impact on tumor growth or overall survival. Some studies have found an increase in quality of life and a decrease in cancer treatment–related toxicities, but the findings are not conclusive.
- Treatment with intravenous vitamin C generally seems to be well-tolerated and safe, but patients with certain conditions (e.g., iron overload, kidney disease) are at increased risk for serious toxicity.
- Curcumin, a substance found in turmeric, has been studied for its possible effects on cancer development and progression. Because a variety of different products and dosages were tested, and because the studies were brief and included only small numbers of people, there isn’t enough evidence to recommend products that contain curcumin for the treatment of people with cancer.
- Researchers are studying curcumin’s usefulness for alleviating side effects caused by cancer treatment, such as oral mucositis and radiation-induced dermatitis (a skin rash caused by radiation treatment), as well as quality of life.
Beware of Cancer Treatment Frauds
The U.S. Food and Drug Administration (FDA) has warned the public to beware of fraudulent cancer treatments promoted on websites or social media platforms.
Some fraudulent cancer treatments are harmful by themselves, and others can be indirectly harmful because people may delay seeking medical care while they try them, or because the fraudulent product interferes with the effectiveness of proven cancer treatments.
The people who sell fraudulent cancer treatments often market them with claims such as “treats all forms of cancer,” “cures cancer,” “selectively kills cancer cells,” or “more effective than chemotherapy.”
If you’re considering using any anticancer product that you’ve seen in an advertisement, talk with your health care provider first.
Complementary Health Approaches for Cancer Prevention
You can reduce your risk of cancer in several ways—including making healthy choices (such as avoiding tobacco and maintaining a healthy weight), getting recommended vaccines against hepatitis B and human papillomavirus (HPV), and getting appropriate cancer screening tests. Research has also been done to see whether various nutritional approaches might help to prevent cancer.
Vitamin and Mineral Supplements
The U.S. Preventive Services Task Force—an expert group that makes recommendations about the types of health care people should receive to prevent diseases—evaluated the evidence on vitamin and mineral supplements and cancer prevention in 2014. (A 2021 update to the report is underway and is anticipated to give the same advice.) The recommendations state that:
- You shouldn’t take vitamin E supplements to try to prevent cancer. Studies have shown that they don’t work.
- You shouldn’t take beta-carotene supplements to try to prevent cancer. Studies have shown that they don’t work, and they can harm some people, such as those who smoke tobacco.
- For all other vitamin and mineral supplements—including single vitamins or minerals, combinations such as calcium plus vitamin D, and multivitamins—there isn’t enough evidence to say whether they can help prevent cancer. The Task Force didn’t make a recommendation for or against the use of these supplements.
- Studies of green tea and cancer in people have had inconsistent results. Based on current evidence, it isn’t possible to say whether green tea helps to prevent cancer.
- Green tea is believed to be safe when consumed as a beverage in moderate amounts. Liver problems have been reported in a small number of people who took concentrated green tea extracts. Experts suggest that green tea extracts should be taken with food, people with liver problems should not take green tea extracts, and users should discontinue use and consult a health care provider if they develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice (yellowing of the skin or eyes).
Other Nutritional Approaches
Several other dietary supplements, including garlic, Ginkgo biloba, noni, and grape seed extract, have been investigated for possible cancer-preventive effects, but the evidence on these substances is too limited for any conclusions to be reached.
In two large observational studies in which researchers kept track of people over a period of years, people who took glucosamine and chondroitin were less likely to develop colorectal cancer. Because these were observational studies, rather than trials in which people were randomly assigned to take a supplement or a placebo, the results can only provide clues for further research; they can’t prove a cause-and-effect relationship because other factors could be involved.
National Institutes of Health Research on Complementary Health Approaches for Cancer
Some ongoing studies related to complementary approaches and cancer funded by the National Center for Complementary and Integrative Health (NCCIH) or NCI are looking at:
- Whether panaxynol, a substance from American ginseng, can suppress colitis and thereby lower the risk of colon cancer
- The potential value of a multimodal mind and body intervention for reducing fear of cancer recurrence
- Self-administered hypnosis to manage hot flashes (which may be caused by breast cancer treatment)
- The potential value of yoga as a treatment for peripheral neuropathy, a painful side effect of some types of cancer chemotherapy
More To Consider
- Gather information about the complementary health product or practice that interests you, and then discuss it with your health care providers. If you’ve been diagnosed with cancer, it’s especially important to talk with your health care providers before you start using any new complementary health approach. If you’re already using a complementary approach, tell your health care providers about it, even if your reason for using it has nothing to do with cancer. Here are examples of questions to ask:
- What is known about the benefits and risks of this product or practice? Do the benefits outweigh the risks?
- What are the potential side effects?
- Will this approach interfere with my cancer treatment?
- Can you refer me to a practitioner?
- Don’t use any health product or practice that has not been proven safe and effective to replace conventional cancer care or as a reason to postpone seeing your health care provider about any health problem.
- Take charge of your health—talk with your health care providers about any complementary health approaches you use. Together, you can make shared, well-informed decisions.
For More Information
The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.
Toll-free in the U.S.: 1-888-644-6226
Telecommunications relay service (TRS): 7-1-1
Email: firstname.lastname@example.org (link sends email)
National Cancer Institute (NCI)
The National Cancer Institute is the Federal Government's lead agency for cancer research. The National Cancer Institute's Office of Cancer Complementary and Alternative Medicine coordinates and enhances the National Cancer Institute's activities in research on complementary health approaches.
Toll-free in the U.S.: 1-800-4-CANCER (1-800-422-6237)
Email: email@example.com (link sends email)
NCI’s Office of Cancer Complementary and Alternative Medicine
NCI’s Office of Cancer Complementary and Alternative Medicine coordinates and enhances NCI’s activities in research on complementary health approaches.
Information on complementary health approaches in cancer treatment: www.cancer.gov/publications/pdq/information-summaries/cam
Know the Science
NCCIH and the National Institutes of Health (NIH) provide tools to help you understand the basics and terminology of scientific research so you can make well-informed decisions about your health. Know the Science features a variety of materials, including interactive modules, quizzes, and videos, as well as links to informative content from Federal resources designed to help consumers make sense of health information.
A service of the National Library of Medicine, PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed.
NIH Clinical Research Trials and You
The National Institutes of Health (NIH) has created a website, NIH Clinical Research Trials and You, to help people learn about clinical trials, why they matter, and how to participate. The site includes questions and answers about clinical trials, guidance on how to find clinical trials through ClinicalTrials.gov and other resources, and stories about the personal experiences of clinical trial participants. Clinical trials are necessary to find better ways to prevent, diagnose, and treat diseases.
- Collinge W, MacDonald G, Walton T. Massage in supportive cancer care. Seminars in Oncology Nursing. 2012;28(1):45-54.
- Crichton M, Marshall S, Marx W, et al. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic review update and meta-analysis. Journal of the Academy of Nutrition and Dietetics. 2019;119(12):2055-2068.
- Deng GE, Frenkel M, Cohen L, et al. Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. Journal of the Society for Integrative Oncology. 2009;7(3):85-120.
- Eastman KL, McFarland LV, Raugi GJ. A review of topical corrosive black salve. Journal of Alternative and Complementary Medicine. 2014;20(4):284-289.
- Filippini T, Malavolti M, Borrelli F, et al. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database of Systematic Reviews. 2020;3(3):CD005004. Accessed at cochranelibrary.com on September 9, 2021.
- Gonzalez M, Pascoe MC, Yang G, et al. Yoga for depression and anxiety symptoms in people with cancer: a systematic review and meta-analysis. Psychooncology. 2021;30(8):1196-1208.
- He Y, Guo X, May BH, et al. Clinical evidence for association of acupuncture and acupressure with improved cancer pain: a systematic review and meta-analysis. JAMA Oncology. 2020;6(2):271-278.
- Miller S, Stagl J, Wallerstedt DB, et al. Botanicals used in complementary and alternative medicine treatment of cancer: clinical science and future perspectives. Expert Opinion on Investigational Drugs. 2008;17(9):1353-1364.
- O’Neill M, Samaroo D, Lopez C, et al. The effect of yoga interventions on cancer-related fatigue and quality of life for women with breast cancer: a systematic review and meta-analysis of randomized controlled trials. Integrative Cancer Therapies. 2020;19:1534735420959882.
- Shin E-S, Seo K-H, Lee S-H, et al. Massage with or without aromatherapy for symptom relief in people with cancer. Cochrane Database of Systematic Reviews. 2016;(6):CD009873. Accessed at cochranelibrary.com on September 14, 2021.
- Towler P, Molassiotis A, Brearley SG. What is the evidence for the use of acupuncture as an intervention for symptom management in cancer supportive and palliative care: an integrative overview of reviews. Supportive Care in Cancer. 2013;21(10):2913-2923.
- U.S. Preventive Services Task Force. Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer. U.S. Preventive Services Task Force website. Accessed at uspreventiveservicestaskforce.org/uspstf/recommendation/vitamin-supplementation-to-prevent-cvd-and-cancer-preventive-medication on September 14, 2021.
- Adler BL, Friedman AJ. Safety and efficacy of agents used for home mole removal and skin cancer treatment in the internet age, and analysis of cases. Journal of Drugs in Dermatology. 2013;12(9):1058-1063.
- Ahmad FB, Anderson RN. The leading causes of death in the US for 2020. JAMA. 2021;325(18):1829-1830.
- Ambrosone CB, Zirpoli GR, Hutson AD, et al. Dietary supplement use during chemotherapy and survival outcomes of patients with breast cancer enrolled in a cooperative group clinical trial (SWOG S0221). Journal of Clinical Oncology. 2020;38(8):804-814.
- Arslan D, Tural D, Akar E. Herbal administration and interaction of cancer treatment. Journal of Palliative Medicine. 2013;16(11):1466-1476.
- Biggs ML, Sorkin BC, Nahin RL, et al. Ginkgo biloba and risk of cancer: secondary analysis of the Ginkgo Evaluation of Memory (GEM) study. Pharmacoepidemiology and Drug Safety. 2010;19(7):694-698.
- Birdee GS, Wayne PM, Davis RB, et al. T’ai chi and qigong for health: patterns of use in the United States. Journal of Alternative and Complementary Medicine. 2009;15(9):969-973.
- Brasky TM, Kristal AR, Navarro SL, et al. Specialty supplements and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohort. Nutrition and Cancer. 2011;63(4):573-582.
- Carlson LE, Toivonen K, Flynn M, et al. The role of hypnosis in cancer care. Current Oncology Reports. 2018;20(12):93.
- Centers for Disease Control and Prevention. How To Prevent Cancer or Find It Early. Accessed at cdc.gov/cancer/dcpc/prevention on September 9, 2021.
- Chen Y-P, Liu T, Peng Y-Y, et al. Acupuncture for hot flashes in women with breast cancer: a systematic review. Journal of Cancer Research and Therapeutics. 2016;12(2):535-542.
- Chien T-J, Hsu C-H, Liu C-Y, et al. Effect of acupuncture on hot flush and menopause symptoms in breast cancer: a systematic review and meta-analysis. PLoS One. 2017;12(8):e0180918.
- Clairet A-L, Boiteux-Jurain M, Curtit E, et al. Interaction between phytotherapy and oral anticancer agents: prospective study and literature review. Medical Oncology. 2019;36(5):45.
- Cramer H, Krucoff C, Dobos G. Adverse events associated with yoga: a systematic review of published case reports and case series. PloS One. 2013;8(10):e75515.
- Cramer H, Ostermann T, Dobos G. Injuries and other adverse events associated with yoga practice: a systematic review of epidemiological studies. Journal of Science and Medicine in Sport. 2018;21(2):147-154.
- Cramer H, Ward L, Saper R, et al. The safety of yoga: a systematic review and meta-analysis of randomized controlled trials. American Journal of Epidemiology. 2015;182(4):281-293.
- Croaker A, King GJ, Pyne JH, et al. A review of black salve: cancer specificity, cure, and cosmesis. Evidence-Based Complementary and Alternative Medicine. 2017;2017:9184034.
- Cui H, Wang Q, Pedersen M, et al. The safety of tai chi: a meta-analysis of adverse events in randomized controlled trials. Contemporary Clinical Trials. 2019;82:85-92.
- Elad S, Meidan I, Sellam G, et al. Topical curcumin for the prevention of oral mucositis in pediatric patients: case series. Alternative Therapies in Health and Medicine. 2013;19(3):21-24.
- Ernst E, Lee MS. Acupuncture for palliative and supportive cancer care: a systematic review of systematic reviews. Journal of Pain and Symptom Management. 2010;40(1):e3-e5.
- Farhat Z, Hershberger PA, Freudenheim JL, et al. Types of garlic and their anticancer and antioxidant activity: a review of the epidemiologic and experimental evidence. European Journal of Nutrition. 2021;60(7):3585-3609.
- Francis M, Williams S. Effectiveness of Indian turmeric powder with honey as complementary therapy on oral mucositis: a nursing perspective among cancer patients in Mysore. Nursing Journal of India. 2014;105(6):258-260.
- Fritz H, Flower G, Weeks L, et al. Intravenous vitamin C and cancer: a systematic review. Integrative Cancer Therapies. 2014;13(4):280-300.
- Garcia MK, McQuade J, Haddad R, et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. Journal of Clinical Oncology. 2013;31(7):952-960.
- Haefeli WE, Carls A. Drug interactions with phytotherapeutics in oncology. Expert Opinion on Drug Metabolism and Toxicology. 2014;10(3):359-377.
- Jung AY, Cai X, Thoene K, et al. Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy. American Journal of Clinical Nutrition. 2019;109(1):69-78.
- Kantor ED, Zhang X, Wu K, et al. Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: results from the Nurses’ Health Study and Health Professionals Follow-Up Study. International Journal of Cancer. 2016;139(9):1949-1957.
- Kravits K. Hypnosis: adjunct therapy for cancer pain management. Journal of the Advanced Practitioner in Oncology. 2013;4(2):83-88.
- Latte-Naor S, Mao JJ. Putting integrative oncology into practice: concepts and approaches. Journal of Oncology Practice. 2019;15(1):7-14.
- Leecy TN, Beer TW, Harvey NT, et al. Histopathological features associated with application of black salve to cutaneous lesions: a series of 16 cases and review of the literature. Pathology. 2013;45(7):670-674.
- Lim A. Black salve treatment of skin cancer: a review. Journal of Dermatological Treatment. 2018;29(4):388-392.
- Lipton L. Using yoga to treat disease: an evidence-based review. Journal of the American Academy of Physician Assistants. 2008;21(2):34-36, 38, 41.
- Liu L, Tan H, Yu S, et al. The effectiveness of tai chi in breast cancer patients: a systematic review and meta-analysis. Complementary Therapies in Clinical Practice. 2020;38:101078.
- Lustyk MKB, Chawla N, Nolan RS, et al. Mindfulness meditation research: issues of participant screening, safety procedures, and researcher training. Advances in Mind-Body Medicine. 2009;24(1):20-30.
- Moyer VA, U.S. Preventive Services Task Force. Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine. 2014;160(8):558-564.
- Nakayama A, Alladin KP, Igbokwe O, et al. Systematic review: generating evidence-based guidelines on the concurrent use of dietary antioxidants and chemotherapy or radiotherapy. Cancer Investigation. 2011;29(10):655-667.
- National Cancer Institute. Curcumin (Curcuma, Turmeric) and Cancer (PDQ®)—Health Professional Version. National Cancer Institute website. Accessed at cancer.gov/about-cancer/treatment/cam/hp/curcumin-pdq on July 30, 2021.
- National Cancer Institute. High-Dose Vitamin C (PDQ®)—Health Professional Version. National Cancer Institute website. Accessed at cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq on August 31, 2021.
- National Cancer Institute. Laetrile/Amygdalin (PDQ®)—Health Professional Version. National Cancer Institute website. Accessed at cancer.gov/about-cancer/treatment/cam/hp/laetrile-pdq on August 31, 2021.
- National Cancer Institute. Tea and Cancer Prevention. National Cancer Institute website. Accessed at cancer.gov/cancertopics/causes-prevention/risk/diet/tea-fact-sheet on October 8, 2021.
- Oketch-Rabah HA, Roe AL, Rider CV, et al. United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts. Toxicology Reports. 2020;7:386-402.
- Panahi Y, Saadat A, Beiraghdar F, et al. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytotherapy Research. 2014;28(10):1461-1467.
- Pawlus AD, Su B-N, Deng Y, et al. Noni. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:570-576.
- Ryan JL, Heckler CE, Ling M, et al. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiation Research. 2013;180(1):34-43.
- Salehi A, Marzban M, Zadeh AR. Acupuncture for treating hot flashes in breast cancer patients: an updated meta-analysis. Supportive Care in Cancer. 2016;24(12):4895-4899.
- Satia JA, Littman A, Slatore CG, et al. Associations of herbal and specialty supplements with lung and colorectal cancer risk in the VITamins And Lifestyle study. Cancer Epidemiology, Biomarkers and Prevention. 2009;18(5):1419-1428.
- Shi J, Chen Q, Xu M, et al. Recent updates and future perspectives about amygdalin as a potential anticancer agent: a review. Cancer Medicine. 2019;8(6):3004-3011.
- Swain TA, McGwin G. Yoga-related injuries in the United States from 2001 to 2014. Orthopaedic Journal of Sports Medicine. 2016;4(11):2325967116671703.
- U.S. Food and Drug Administration. Products Claiming To “Cure” Cancer Are a Cruel Deception. Accessed at fda.gov/consumers/consumer-updates/products-claiming-cure-cancer-are-cruel-deception on September 9, 2021.
- Vernieri C, Nichetti F, Raimondi A, et al. Diet and supplements in cancer prevention and treatment: clinical evidences and future perspectives. Critical Reviews in Oncology/Hematology. 2018;123:57-73.
- Xu S, Wang L, Cooper E, et al. Adverse events of acupuncture: a systematic review of case reports. Evidence-Based Complementary and Alternative Medicine. 2013;2013:581203.
- Xunlin NG, Lau Y, Klainin-Yobas P. The effectiveness of mindfulness-based interventions among cancer patients and survivors: a systematic review and meta-analysis. Supportive Care in Cancer. 2020;28(4):1563-1578
- Yao C, Cheng Y, Zhu Q, et al. Clinical evidence for the effects of manual therapy on cancer pain: a systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine. 2021;2021;6678184.
- Zeng Y, Xie X, Cheng ASK. Qigong or tai chi in cancer care: an updated systematic review and meta-analysis. Current Oncology Reports. 2019;21(6):48.
- Zhang Y, Lin L, Li H, et al. Effects of acupuncture on cancer-related fatigue: a meta-analysis. Supportive Care in Cancer. 2018;26(2):415-425.
NCCIH thanks Jeffrey White, M.D., Oluwadamilola Olaku, M.D., M.P.H., Sophie King, M.S., and Megan Sansevere, M.S., of NCI’s Office of Cancer Complementary and Alternative Medicine, and David Shurtleff, Ph.D., of NCCIH for their review of the 2021 update of this publication.
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